Functionally-Guided Multiomics Profiling of Human Systemic Inflammation Identifies Myeloid Therapeutic Targets

In our latest talk and poster presentation at the Keystone Autoimmunity & Autoinflammation symposium, Graph’s co-founder and CSO Bojan Vilagos, PhD presented our generalizable and scalable approach for discovering shared mechanisms across disease contexts. Focusing on the NLR-specific endpoint of endogenous ASC-speckling in sterile inflammation, we mapped systemic responses by using our platform for fast, patient-first I&I discovery.

To better understand how immune cells jointly behave in a complex inflammatory environment, the Graph team profiled millions of primary immune cells in a disease-relevant systemic inflammation condition, and identified numerous hits that affect inflammasome modulation in monocytes.